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Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity.

Abstract:

The human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates the HTLV-1 long terminal repeat and key regulatory proteins involved in inflammation, activation, and proliferation and may induce cell transformation. Tax is also the immunodominant target antigen for cytotoxic T cells in HTLV-1 infection. We found that Tax bound to assembled nuclear proteasomes, but Tax could not be detected in the cytoplasm. Confocal microscopy revealed a partial colocalization of Tax with nuclear protea...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Role:
Author
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Journal:
Journal of virology
Volume:
75
Issue:
22
Pages:
11106-11115
Publication date:
2001-11-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:b1716122-05a6-4dd5-9a47-0f822e208b85
Source identifiers:
31965
Local pid:
pubs:31965

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