Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells.

Journal article

Degradation of the extracellular matrix components elastin and collagen has been implicated in vascular diseases, including abdominal aortic aneurysm (AAA) and atherosclerotic plaque rupture. Increased expression of matrix metalloproteinases (MMPs) is involved in these disease processes. Our previous studies have demonstrated that MMP-2 derived from mesenchymal cells is required for aneurysm development in a murine model. Doxycycline is a nonspecific inhibitor of MMPs. In the present study, t...

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Authors: Liu, J; Xiong, W; Baca-Regen, L; Nagase, H; Baxter, B

• Publication status: Published
• Journal: Journal of vascular surgery
• Volume: 38
• Issue: 6
• Pages: 1376-1383
• Publication date: 2003-12-01
• DOI: 10.1016/s0741-5214(03)01022-x
• EISSN: 1097-6809
• ISSN: 0741-5214
• Language: English
• Keywords: Matrix Metalloproteinase 2; Humans; Matrix Metalloproteinase Inhibitors; Anti-Bacterial Agents; Aortic Aneurysm, Abdominal; Doxycycline; Gene Expression; Myocytes, Smooth Muscle