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Journal article

Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells.

Abstract:

Degradation of the extracellular matrix components elastin and collagen has been implicated in vascular diseases, including abdominal aortic aneurysm (AAA) and atherosclerotic plaque rupture. Increased expression of matrix metalloproteinases (MMPs) is involved in these disease processes. Our previous studies have demonstrated that MMP-2 derived from mesenchymal cells is required for aneurysm development in a murine model. Doxycycline is a nonspecific inhibitor of MMPs. In the present study, t...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Journal of vascular surgery
Volume:
38
Issue:
6
Pages:
1376-1383
Publication date:
2003-12-01
DOI:
EISSN:
1097-6809
ISSN:
0741-5214
Source identifiers:
227017
Language:
English
Keywords:
Pubs id:
pubs:227017
UUID:
uuid:b16fed16-b4fa-41e6-b63c-a2dee0f21ff2
Local pid:
pubs:227017
Deposit date:
2012-12-19

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