- Abstract:
-
GPR39 is a G-protein-coupled zinc receptor that protects against diverse effectors of cell death. Its protective activity is mediated via constitutive activation of Gα13 and the RhoA pathway, leading to increased SRE (serum-response element)-dependent transcription; the zinc-dependent immediate activation of GPR39 involves Gq-mediated increases in cytosolic Ca2+ and Gs coupling leading to increased cAMP levels. We used the cytosolic and soluble C-terminus of GPR39 in a Y2H (yeast-2-hybrid) sc...
Expand abstract - Publisher copy:
- 10.1042/bj20131198
-
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- Publisher:
- Portland Press Ltd
- Journal:
- The Biochemical journal
- Volume:
- 462
- Issue:
- 1
- Pages:
- 125-132
- Publication date:
- 2014-08-05
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- URN:
-
uuid:b168ade1-3142-4dbd-8d71-a854adbfd1d1
- Source identifiers:
-
466213
- Local pid:
- pubs:466213
- Copyright date:
- 2014
Journal article
Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.
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