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Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.

Abstract:

GPR39 is a G-protein-coupled zinc receptor that protects against diverse effectors of cell death. Its protective activity is mediated via constitutive activation of Gα13 and the RhoA pathway, leading to increased SRE (serum-response element)-dependent transcription; the zinc-dependent immediate activation of GPR39 involves Gq-mediated increases in cytosolic Ca2+ and Gs coupling leading to increased cAMP levels. We used the cytosolic and soluble C-terminus of GPR39 in a Y2H (yeast-2-hybrid) sc...

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Publisher copy:
10.1042/bj20131198

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Publisher:
Portland Press Ltd
Journal:
The Biochemical journal
Volume:
462
Issue:
1
Pages:
125-132
Publication date:
2014-08-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:b168ade1-3142-4dbd-8d71-a854adbfd1d1
Source identifiers:
466213
Local pid:
pubs:466213

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