Total and Gleason grade 4/5 cancer volumes are major contributors of human kallikrein 2, whereas free prostate specific antigen is largely contributed by benign gland volume in serum from patients with prostate cancer or benign prostatic biopsies.

Journal article

PURPOSE: We measured concentrations of human glandular kallikrein 2 (hK2), total prostate specific antigen (tPSA), free PSA (fPSA) and percent fPSA to evaluate their relationship to total prostate gland volume, benign prostatic hyperplasia (BPH) volume, total prostate cancer (PCa) volume (CaVol) and the volume of Gleason grades 4/5 cancer (CaVolGl4) in the serum of 256 patients with PCa undergoing radical retropubic prostatectomy and 185 with negative systematic sextant biopsies. MATERIALS A...

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Authors: Haese, A; Graefen, M; Steuber, T; Becker, C; Noldus, J

• Journal: Journal of urology
• Volume: 170
• Issue: 6 Pt 1
• Pages: 2269-2273
• Publication date: 2003-12-01
• DOI: 10.1097/01.ju.0000095794.04551.0c
• EISSN: 1527-3792
• ISSN: 0022-5347
• Language: English
• Keywords: Tissue Kallikreins; Humans; Prostatic Neoplasms; Male; Prostate; Prostatic Hyperplasia; Prostate-Specific Antigen; Fluoroimmunoassay