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Protein targeting of an unusual, evolutionarily conserved adenylate kinase to a eukaryotic flagellum

Abstract:

The eukaryotic flagellum is a large structure into which specific constituent proteins must be targeted, transported and assembled after their synthesis in the cytoplasm. Using Trypanosoma brucei and a proteomic approach, we have identified and characterized a novel set of adenylate kinase proteins that are localized to the flagellum. These proteins represent unique isoforms that are targeted to the flagellum by an N-terminal extension to the protein and are incorporated into an extraaxonemal...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1091/mbc.E04-03-0217

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Institution:
University of Oxford
Department:
Medical Sciences Division - Pathology
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Institution:
University of Oxford
Department:
Medical Sciences Division - Pathology
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Institution:
University of Manchester Institute of Science and Technology
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Institution:
University of Oxford
Department:
Medical Sciences Division - Pathology
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Funding agency for:
Michael L. Ginger
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Funding agency for:
Keith Gull
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Publisher:
The American Society for Cell Biology Publisher's website
Journal:
Molecular Biology of the Cell Journal website
Volume:
15
Issue:
7
Pages:
3257-3265
Publication date:
2004-07-05
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
URN:
uuid:b15dcc01-578b-4e57-bbb1-711171040b3d
Local pid:
ora:1523

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