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Thesis

The influence of BRCA1's ubiquitin ligase activity on cell motility

Abstract:

Breast cancer type 1 susceptibility protein (BRCA1) has been established as an important tumour suppressor protein and its loss of function is associated with hereditary breast and ovarian cancer. An emerging body of work suggests that BRCA1 is involved in sporadic cases of breast and ovarian cancers and may also have a role in other cancers, indicating a more global role in tumourigenesis. BRCA1-mutated cancers can be early-onset and are characterised by being highly aggressive with a ...

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Institution:
University of Oxford
Research group:
Vaux Group
Oxford college:
Keble College
Department:
Medical Sciences Division - Pathology

Contributors

Role:
Supervisor
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Funding agency for:
Sameer Sengupta
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:b14af4ae-1f95-4d0c-85a8-faaf4fa950c4
Local pid:
ora:8577

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