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beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy.

Abstract:

A novel strategy for improving the treatment of depressive illness is augmentation of antidepressants with a 5-HT1(1A) autoreceptor antagonist. However, trials using the 5-HT1(1A)/beta-blocker pindolol are proving inconsistent. We report how positron emission tomography (PET) and in vitro autoradiography can inform trials of antidepressant augmentation. We show that in healthy volunteers, in vivo, pindolol (n = 10) and penbutolol (n = 4), but not tertatolol (n = 4) occupy the human 5-HT(1A) r...

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Publication status:
Published

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Authors


Rabiner, EA More by this author
Castro, ME More by this author
Sargent, PA More by this author
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Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
23
Issue:
3
Pages:
285-293
Publication date:
2000-09-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:b1357749-ef64-48c9-9784-1842b445bb9c
Source identifiers:
98163
Local pid:
pubs:98163

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