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beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy.

Abstract:

A novel strategy for improving the treatment of depressive illness is augmentation of antidepressants with a 5-HT1(1A) autoreceptor antagonist. However, trials using the 5-HT1(1A)/beta-blocker pindolol are proving inconsistent. We report how positron emission tomography (PET) and in vitro autoradiography can inform trials of antidepressant augmentation. We show that in healthy volunteers, in vivo, pindolol (n = 10) and penbutolol (n = 4), but not tertatolol (n = 4) occupy the human 5-HT(1A) r...

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Publication status:
Published

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Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
23
Issue:
3
Pages:
285-293
Publication date:
2000-09-01
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
Source identifiers:
98163

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