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Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients.

Abstract:

HIV-1 samples from six patients undergoing diverse anti-HIV therapies possessed the E138A mutation in their reverse transcriptase (RT) genome. Patients were receiving the following therapies: TIBO monotherapy (one patient); zidovudine plus didanosine combination therapy (one); zidovudine monotherapy (one); sequential therapy with zidovudine, then stavudine and finally zalcitabine plus didanosine (one); and two were drug naive. E138K, not E138A, is a known TSAO-specific resistance mutation, em...

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Publication status:
Published

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Publisher copy:
10.1089/08892220050042765

Authors


Van Laethem, K More by this author
Schmit, JC More by this author
Pelemans, H More by this author
Balzarini, J More by this author
Witvrouw, M More by this author
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Journal:
AIDS research and human retroviruses
Volume:
16
Issue:
9
Pages:
825-833
Publication date:
2000-06-05
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
URN:
uuid:b122a42f-ddd0-49cf-8f52-066156f29943
Source identifiers:
20975
Local pid:
pubs:20975

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