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Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases.

Abstract:

Ferrous iron and 2-oxoglutarate-dependent oxygenases and related enzymes catalyse a range of oxidative reactions, possibly the widest of any enzyme family. Their catalytic flexibility is proposed to be related to their nonhaem iron-binding site, which utilizes two or three protein-based ligands. A possible penalty for this flexibility is that they may be more prone to oxidative damage than the P450 oxidases, where the iron is arguably located in a more controlled environment. We review the ev...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
The FEBS journal
Volume:
279
Issue:
9
Pages:
1563-1575
Publication date:
2012-05-05
DOI:
EISSN:
1742-4658
ISSN:
1742-464X
URN:
uuid:b10cee21-71c2-4327-a028-ee36cd77655f
Source identifiers:
237186
Local pid:
pubs:237186

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