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Diagnosis of Streptococcus pneumoniae infections in adults with bacteremia and community-acquired pneumonia: clinical comparison of pneumococcal PCR and urinary antigen detection.

Abstract:

The diagnosis of severe Streptococcus pneumoniae infection relies heavily on insensitive culture techniques. To improve the usefulness of PCR assays, we developed a dual-PCR protocol (targeted at pneumolysin and autolysin) for EDTA blood samples. This was compared to the Binax NOW S. pneumoniae urine antigen test in patients with bacteremic pneumococcal infections. Patients with nonbacteremic community-acquired pneumonia also were tested by these methods to determine what proportion could be ...

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Publication status:
Published

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Publisher copy:
10.1128/jcm.01480-08

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Journal:
Journal of clinical microbiology
Volume:
47
Issue:
4
Pages:
1046-1049
Publication date:
2009-04-05
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
URN:
uuid:b1088307-d9e8-4d1d-bb67-e6d4bcdaccd0
Source identifiers:
317066
Local pid:
pubs:317066

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