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The need for randomization in animal trials: an overview of systematic reviews

Abstract:

BACKGROUND AND OBJECTIVES: Randomization, allocation concealment, and blind outcome assessment have been shown to reduce bias in human studies. Authors from the Collaborative Approach to Meta Analysis and Review of Animal Data from Experimental Studies (CAMARADES) collaboration recently found that these features protect against bias in animal stroke studies. We extended the scope the work from CAMARADES to include investigations of treatments for any condition. METHODS: We conducted an overvi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0098856

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Madox
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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-EBM
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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
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Institution:
University of Oxford
Department:
The Bodleian Health Care Libraries
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, Biomedical RC
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
9
Issue:
6
Pages:
e98856
Publication date:
2014-05-07
Acceptance date:
2014-06-06
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:b10553e7-529f-4e5e-b4ea-62bbcba7f5fe
Source identifiers:
469108
Local pid:
pubs:469108

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