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Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.

Abstract:

Animals employ two systems for the de novo biosynthesis of fatty acids: a megasynthase complex in the cytosol (type I) that produces mainly palmitate, and an ensemble of freestanding enzymes in the mitochondria (type II) that produces mainly octanoyl moieties. The acyltransferases responsible for initiation of fatty acid biosynthesis in the two compartments are distinguished by their different substrate specificities: the type I enzyme transfers both the acetyl primer and the malonyl chain ex...

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Publication status:
Published

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Journal:
Chemistry and biology
Volume:
16
Issue:
6
Pages:
667-675
Publication date:
2009-06-05
DOI:
EISSN:
1879-1301
ISSN:
1074-5521
URN:
uuid:b105244e-e8c5-4109-901f-90bb92013454
Source identifiers:
108723
Local pid:
pubs:108723

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