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Journal article

Novel loci discovery for blood pressure and heart rate using the Exome chip

Abstract:

Introduction: Genome-wide association studies for many cardiovascular traits have primarily identified common variants with small effects, explaining only a small percentage of the total trait variance. The missing heritability may in part be explained by rare variants.

Methods: The Exome chip includes ~250,000 rare, low-frequency and common variants, thus enables the investigation of rare variant associations.

Within large international consortia, we have led ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/jhh.2016.60

Authors


Warren, HR More by this author
Surendran, P More by this author
Manning, AK More by this author
van den Berg, ME More by this author
van der Harst, P More by this author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Journal of Human Hypertension Journal website
Volume:
30
Issue:
10
Pages:
653-653
Publication date:
2016-10-01
DOI:
EISSN:
1476-5527
ISSN:
0950-9240
Pubs id:
pubs:718599
URN:
uri:b104b9d0-09de-4c71-b79e-b0fd1a2c92a9
UUID:
uuid:b104b9d0-09de-4c71-b79e-b0fd1a2c92a9
Local pid:
pubs:718599

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