Novel loci discovery for blood pressure and heart rate using the Exome chip
Introduction: Genome-wide association studies for many cardiovascular traits have primarily identified common variants with small effects, explaining only a small percentage of the total trait variance. The missing heritability may in part be explained by rare variants.
Methods: The Exome chip includes ~250,000 rare, low-frequency and common variants, thus enables the investigation of rare variant associations.
Within large international consortia, we have led ...Expand abstract
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- This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/jhh.2016.60. This is a poster abstract from the 2016 Annual Scientific Meeting of the BHS.