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Journal article

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.

Abstract:

DNA base excision repair (BER) is an essential cellular process required for genome stability, and misregulation of BER is linked to premature aging, increased rate of mutagenesis, and cancer. We have now identified the cytoplasmic ubiquitin-specific protease USP47 as the major enzyme involved in deubiquitylation of the key BER DNA polymerase (Pol β) and demonstrate that USP47 is required for stability of newly synthesized cytoplasmic Pol β that is used as a source for nuclear Pol β involved ...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
41
Issue:
5
Pages:
609-615
Publication date:
2011-03-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:b0f61615-5aaa-46f0-bb61-f4f262a977fc
Source identifiers:
120206
Local pid:
pubs:120206

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