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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Abstract:

The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in rodents. In contrast, information regarding the roles of this hormone in humans is limited. Three morbidly obese children, who were congenitally deficient in leptin, were treated with daily subcutaneous injections of recombinant human leptin for up to 4 years wit...

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Publisher copy:
10.1172/jci0215693

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Journal:
The Journal of clinical investigation
Volume:
110
Issue:
8
Pages:
1093-1103
Publication date:
2002-10-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:b0f4d144-ee63-486d-9c39-f02d16b963ee
Source identifiers:
429903
Local pid:
pubs:429903

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