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Do L3T4+ T cells act as effector cells in protection against influenza virus infection.

Abstract:

This study aimed to analyse the roles of Lyt 2+ and L3T4+ memory T-cell subpopulations in murine influenza infection. Previous work has shown that Lyt 2+ cytotoxic T-cell (Tc) clones can adoptively transfer protection. We therefore wished to see whether L3T4+ (Th) cells could also act as protective effector cells. Donors for adoptive cell transfer were thymectomized mice, depleted in vivo of either Lyt 2+ or L3T4+ T cells with monoclonal antibodies (MAb) and then infected with influenza virus...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Immunology
Volume:
62
Issue:
1
Pages:
139-144
Publication date:
1987-09-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:b0f1a85c-f82e-468d-b54b-35592c5aec75
Source identifiers:
16494
Local pid:
pubs:16494

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