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Thesis

Understanding the role of islet development in type 2 diabetes susceptibility

Abstract:

Most variants associated with type 2 diabetes (T2D) predisposition in genome-wide association studies (GWAS) act through defects in insulin secretion. In principle, these could result from deficiencies in islet development and/or mature islet function: most functional studies have focused on the latter. To explore the contribution of disturbed islet development to T2D pathogenesis, I characterised the transcriptome (using RNA-seq), accessible chromatin (ATAC-seq), H3K27ac histone marks (Ch...

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Institution:
University of Oxford
Division:
MSD
Department:
Doctoral Training Centre - MSD
Research group:
McCarthy
Oxford college:
Merton College
Role:
Author
ORCID:
https://orcid.org/0000-0002-7767-1940

Contributors

Division:
MSD
Department:
Doctoral Training Centre - MSD
Oxford college:
Merton College
Role:
Supervisor
Division:
MSD
Department:
Doctoral Training Centre - MSD
Oxford college:
Merton College
Role:
Supervisor
More from this funder
Grant:
H5R00430
Funding agency for:
Pérez Alcántara, M
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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