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Evidence for genetic basis of multiple sclerosis. The Canadian Collaborative Study Group.

Abstract:

BACKGROUND Increased familial risks in multiple sclerosis (MS) range from 300-fold for monozygotic twins to 20-40-fold for biological first-degree relatives, suggesting a genetic influence. Yet if one identical twin has MS the other usually will not. One way of sorting out the contributions of genes and environment is to study half-sibs. METHODS In a Canadian population-based sample of 16 000 MS cases seen at 14 regional MS clinics one half-sib (or more) was reported by 939 index cases. By in...

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Authors


Sadovnick, AD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Dyment, DA More by this author
Journal:
Lancet
Volume:
347
Issue:
9017
Pages:
1728-1730
Publication date:
1996-06-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:b0e02f59-78fb-4048-af86-39adae773a89
Source identifiers:
35926
Local pid:
pubs:35926

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