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Journal article

Extracellular interactions between GluR2 and N-cadherin in spine regulation.

Abstract:

Via its extracellular N-terminal domain (NTD), the AMPA receptor subunit GluR2 promotes the formation and growth of dendritic spines in cultured hippocampal neurons. Here we show that the first N-terminal 92 amino acids of the extracellular domain are necessary and sufficient for GluR2's spine-promoting activity. Moreover, overexpression of this extracellular domain increases the frequency of miniature excitatory postsynaptic currents (mEPSCs). Biochemically, the NTD of GluR2 can interact dir...

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Journal:
Neuron
Volume:
54
Issue:
3
Pages:
461-477
Publication date:
2007-05-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:b0da3aae-2748-4e8d-a326-35f823f3af44
Source identifiers:
411464
Local pid:
pubs:411464

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