Journal article
Extracellular interactions between GluR2 and N-cadherin in spine regulation.
- Abstract:
-
Via its extracellular N-terminal domain (NTD), the AMPA receptor subunit GluR2 promotes the formation and growth of dendritic spines in cultured hippocampal neurons. Here we show that the first N-terminal 92 amino acids of the extracellular domain are necessary and sufficient for GluR2's spine-promoting activity. Moreover, overexpression of this extracellular domain increases the frequency of miniature excitatory postsynaptic currents (mEPSCs). Biochemically, the NTD of GluR2 can interact dir...
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- Publisher copy:
- 10.1016/j.neuron.2007.04.012
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Authors
Bibliographic Details
- Journal:
- Neuron
- Volume:
- 54
- Issue:
- 3
- Pages:
- 461-477
- Publication date:
- 2007-05-01
- DOI:
- EISSN:
-
1097-4199
- ISSN:
-
0896-6273
- Source identifiers:
-
411464
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:411464
- UUID:
-
uuid:b0da3aae-2748-4e8d-a326-35f823f3af44
- Local pid:
- pubs:411464
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2007
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