Condensin confers the longitudinal rigidity of chromosomes.

Journal article

In addition to inter-chromatid cohesion, mitotic and meiotic chromatids must have three physical properties: compaction into 'threads' roughly co-linear with their DNA sequence, intra-chromatid cohesion determining their rigidity, and a mechanism to promote sister chromatid disentanglement. A fundamental issue in chromosome biology is whether a single molecular process accounts for all three features. There is universal agreement that a pair of Smc-kleisin complexes called condensin I and II ...

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Authors: Houlard, M; Godwin, J; Metson, J; Lee, J; Hirano, T

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Publishing Group
• Journal: Nature cell biology
• Volume: 17
• Issue: 6
• Pages: 771-781
• Publication date: 2015-05-01
• DOI: 10.1038/ncb3167
• EISSN: 1476-4679
• ISSN: 1465-7392
• Language: English
• Keywords: Mice, Transgenic; Animals; Cell Cycle Proteins; Mice; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Meiosis; Multiprotein Complexes; Nuclear Proteins; Chromosome Segregation; Chromosomes; Chromatids; Oocytes; Adenosine Triphosphatases