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Tetradecanoylphorbol-13-acetate (TPA) significantly increases AAV2/5 transduction of human neuronal cells in vitro.

Abstract:

Recombinant adeno-associated virus type 2 (AAV2) vectors have shown great promise in current ophthalmology clinical trials targeting gene delivery to the retinal pigment epithelium (RPE). To treat the majority of retinal diseases, however, gene delivery would need to be targeted to photoreceptor neurons of the outer retina. AAV2 pseudotyped with the AAV5 capsid (AAV2/5) has shown far greater transduction efficiency in photoreceptors compared to standard AAV2 vectors. For clinical trial applic...

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Publication status:
Published

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Publisher copy:
10.1016/j.exer.2011.12.009

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
McClements, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Journal:
Experimental eye research
Volume:
97
Issue:
1
Pages:
148-153
Publication date:
2012-04-05
DOI:
EISSN:
1096-0007
ISSN:
0014-4835
URN:
uuid:b0c39d1b-f0e4-41c3-adf0-6cf5c2134493
Source identifiers:
222332
Local pid:
pubs:222332

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