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Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCs

Abstract:

Maturity onset diabetes of the young (MODY) is a hereditary form of diabetes mellitus presenting at childhood or adolescence, which eventually leads to pancreatic β-cells dysfunction. The underlying genetic basis of MODY disorders is haploinsufficiency, where loss-of-function mutations in a single allele cause the diabetic phenotype in heterozygous patients. MODY1 is a type of MODY disorder resulting from a mutation in the transcription factor hepatocyte nuclear factor 4 alpha (HNF4α). In ord...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.scr.2018.06.013

Authors


Braverman-Gross, C More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Strategic
Oxford college:
Green Templeton College
ORCID:
0000-0002-4393-0510
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Rosetrees Trust More from this funder
Azrieli Foundation More from this funder
European Federation of Pharmaceutical Industries and Associations More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Stem Cell Research Journal website
Volume:
31
Pages:
16-26
Publication date:
2018-06-26
Acceptance date:
2018-06-25
DOI:
EISSN:
1876-7753
ISSN:
1873-5061
Pubs id:
pubs:870200
URN:
uri:b0c1efc4-39fa-45ec-a919-80d6698847bb
UUID:
uuid:b0c1efc4-39fa-45ec-a919-80d6698847bb
Local pid:
pubs:870200

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