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The cost of copy number in a selfish genetic element: the 2-μm plasmid of Saccharomyces cerevisiae.

Abstract:

Many autonomously replicating genetic elements exist as multiple copies within the cell. The copy number of these elements is often assumed to have important fitness consequences for both element and host, yet the forces shaping its evolution are not well understood. The 2 μm is a multicopy plasmid of Saccharomyces yeasts, encoding just four genes that are solely involved in plasmid replication. One simple model for the fitness relationship between yeasts and 2 μm is that plasmid copy number ...

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Publication status:
Published

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Authors


Harrison, E More by this author
Koufopanou, V More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Journal:
Journal of evolutionary biology
Volume:
25
Issue:
11
Pages:
2348-2356
Publication date:
2012-11-05
DOI:
EISSN:
1420-9101
ISSN:
1010-061X
URN:
uuid:b0ae5668-74db-45fa-8b7f-4b8b6fda64c0
Source identifiers:
359872
Local pid:
pubs:359872

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