The HIF pathway: implications for patterns of gene expression in cancer.

Journal article

Regulation of the growth and metabolism of large organisms is tightly constrained by the need for precise oxygen homeostasis. Work on control of the haematopoietic growth factor erythropoietin has led to the recognition of a widespread transcriptional response to hypoxia which provides insights into how this is achieved. The central mediator of this response is a DNA binding complex termed hypoxia inducible factor 1 (HIF-1), which plays a key role in the regulation by oxygen of a large and ra...

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Authors: Wykoff, C; Pugh, C; Harris, A; Maxwell, P; Ratcliffe, P

• Journal: Novartis Foundation symposium
• Volume: 240
• Pages: 212-225
• Publication date: 2001-01-01
• EISSN: 1935-4657
• ISSN: 1528-2511
• Language: English
• Keywords: Nuclear Proteins; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Cell Hypoxia; Extracellular Space; Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Humans; Gene Expression Regulation, Neoplastic; Neoplasms; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Trans-Activators; Erythropoietin; von Hippel-Lindau Disease