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Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q.

Abstract:

Myelodysplastic syndromes (MDS) are characterized by abnormal and dysplastic maturation of all blood lineages. Even though epigenetic alterations have been seen in MDS marrow progenitors, very little is known about the molecular alterations in dysplastic peripheral blood cells. We analyzed the methylome of MDS leukocytes by the HELP assay and determined that it was globally distinct from age-matched controls and was characterized by numerous novel, aberrant hypermethylated marks that were loc...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m111.235028

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Journal:
Journal of biological chemistry
Volume:
286
Issue:
28
Pages:
25211-25223
Publication date:
2011-07-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
246257
Language:
English
Keywords:
Pubs id:
pubs:246257
UUID:
uuid:b0781bbe-6237-491f-9944-0336f4cb3a59
Local pid:
pubs:246257
Deposit date:
2013-11-16

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