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A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine.

Abstract:

Fixed-dose combination analgesics are used widely, and available both on prescription and over-the-counter. Combination drugs should provide more analgesia than with any single drug in the combination, but there is no evidence in humans about whether oral combinations have just additive effects, or are synergistic or even subadditive. We suggest that the measured result for the combination would be the summation of the absolute benefit increase (effect of active drug minus effect of placebo) ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Straube, S More by this author
McQuay, HJ More by this author
Journal:
European journal of pain (London, England)
Volume:
16
Issue:
4
Pages:
585-591
Publication date:
2012-04-05
DOI:
EISSN:
1532-2149
ISSN:
1090-3801
URN:
uuid:b0763b1d-e326-4fde-a9d6-71a17538a8f0
Source identifiers:
322927
Local pid:
pubs:322927

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