Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis.

Journal article

BACKGROUND: TRACK-HD is a prospective observational study of Huntington's disease (HD) that examines disease progression in premanifest individuals carrying the mutant HTT gene and those with early stage disease. We report 12-month longitudinal changes, building on baseline findings. METHODS: we did a 12-month follow-up of patients recruited from the four TRACK-HD study sites in Canada, France, the Netherlands, and the UK. Participants were premanifest individuals (preHD) carrying the mutant ...

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Authors: Tabrizi, S; Scahill, R; Durr, A; Roos, R; Leavitt, B

• Publication status: Published
• Journal: Lancet. Neurology
• Volume: 10
• Issue: 1
• Pages: 31-42
• Publication date: 2011-01-01
• DOI: 10.1016/s1474-4422(10)70276-3
• EISSN: 1474-4465
• ISSN: 1474-4422
• Language: English
• Keywords: Movement; Case-Control Studies; Netherlands; Disease Progression; Male; Brain Mapping; Aged; Magnetic Resonance Imaging; Humans; Observation; International Cooperation; Brain; Middle Aged; Cognition Disorders; Canada; Young Adult; Huntington Disease; Nerve Tissue Proteins; TRACK-HD Investigators; Female; Adult; France; Longitudinal Studies; Atrophy; Imaging, Three-Dimensional; Nuclear Proteins