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Journal article

Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia

Abstract:

Intracytoplasmic aggregation of α-synuclein protein as Lewy bodies in the brainstem neurons is diagnostic for Parkinson's disease, whereas if this process also occurs in the cortical neurons, it is considered pathognomonic for dementia with Lewy bodies. However, the link between α-synuclein incorporation into inclusions, neuronal dysfunction, and clinical symptoms needs to be clarified. Another important issue of the pathogenetic puzzle is to understand where α-synuclein pathology begins and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ana.20321

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Finnish Alzheimer Association More from this funder
Kuopio University Hosptial More from this funder
More from this funder
Grant:
QLRI-CT-2000-00066*
Finnish Research Foundation of Orion Corporation More from this funder
Finnish Parkinson Association More from this funder
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Publisher:
Wiley Publisher's website
Journal:
Annals of Neurology Journal website
Volume:
57
Issue:
1
Pages:
82-91
Publication date:
2004-11-23
Acceptance date:
2004-09-18
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
Source identifiers:
579215
Pubs id:
pubs:579215
UUID:
uuid:b06272c5-21cd-4d1d-9574-208500b8956f
Local pid:
pubs:579215
Deposit date:
2015-12-09

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