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Are cellular mechanosensors potential therapeutic targets in osteoarthritis?

Abstract:

The role of mechanical factors in driving osteoarthritis is undisputed, but historically this was largely explained by chronic attrition of the articulating surfaces. The finding that mice deficient in matrix-degrading enzymes were protected from experimental osteoarthritis (OA) suggested an alternative explanation: that mechanosensitive pathways drive the enzymes responsible for cartilage breakdown. Mechanical factors are also important for joint homeostasis and are therefore both good and b...

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Publisher copy:
10.2217/ijr.14.15

Authors


Drexler, S More by this author
Vincent, TL More by this author
Publisher:
Future Medicine Ltd.
Journal:
International Journal of Clinical Rheumatology
Volume:
9
Issue:
2
Pages:
155-167
Publication date:
2014
DOI:
EISSN:
1758-4280
ISSN:
1758-4272
URN:
uuid:b05ff356-8ad1-4e1e-be5e-207c4e0d9be5
Source identifiers:
467115
Local pid:
pubs:467115

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