Are cellular mechanosensors potential therapeutic targets in osteoarthritis?
The role of mechanical factors in driving osteoarthritis is undisputed, but historically this was largely explained by chronic attrition of the articulating surfaces. The finding that mice deficient in matrix-degrading enzymes were protected from experimental osteoarthritis (OA) suggested an alternative explanation: that mechanosensitive pathways drive the enzymes responsible for cartilage breakdown. Mechanical factors are also important for joint homeostasis and are therefore both good and b...Expand abstract
- Publisher copy:
- Future Medicine Ltd.
- International Journal of Clinical Rheumatology
- Publication date:
- Source identifiers:
- Local pid:
- Copyright date:
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record