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Lessons learned from Restoring Study 329: transparent reporting, open databases and network meta-analyses as the way forward

Abstract:

Study 329 is a poster-child for the so-called crisis in evidence-based medicine. Published in 2001 by the Journal for the American Academy of Adolescent Psychiatry (JAACAP), this doubleblind, randomized controlled trial sponsored by GlaxoSmithKline compared paroxetine, imipramine and placebo in the treatment of adolescent major depression. The authors concluded that ‘paroxetine is generally well tolerated and effective for major depression in adolescents’. A nebulous statement, but apparently...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1177/0004867416676372

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Department:
Oxford, MSD, Psychiatry
Role:
Author
Publisher:
SAGE Publisher's website
Journal:
Australian and New Zealand Journal of Psychiatry Journal website
Volume:
51
Issue:
4
Pages:
407-409
Publication date:
2016-11-05
Acceptance date:
2016-09-20
DOI:
EISSN:
1440-1614
ISSN:
0004-8674
Pubs id:
pubs:656464
URN:
uri:b0524f9d-6500-42a3-b439-546cd5dd290f
UUID:
uuid:b0524f9d-6500-42a3-b439-546cd5dd290f
Local pid:
pubs:656464
Paper number:
4

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