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Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte.

Abstract:

Protons are powerful modulators of cardiac function. Their intracellular concentration is regulated by sarcolemmal ion transporters that export or import H+-ions (or their ionic equivalent: HCO3-, OH-). One such transporter, which imports H+-equivalents, is a putative Cl-/OH- exchanger (CHE). A strong candidate for CHE is SLC26A6 protein, a product of the SLC26A gene family of anion transporters, which has been detected in murine heart. SLC26A6 protein is suggested to be an electrogenic 1Cl-/...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.107.118885

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Journal:
Biophysical journal
Volume:
94
Issue:
6
Pages:
2385-2403
Publication date:
2008-03-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:b04a4ad5-f3d7-44e8-82e2-5d3498074776
Source identifiers:
106510
Local pid:
pubs:106510

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