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Plasma and whole blood mefloquine concentrations during treatment of chloroquine-resistant falciparum malaria with the combination mefloquine-sulphadoxine-pyrimethamine.

Abstract:

Mefloquine-sulphadoxine-pyrimethamine (MSP) in combination has proved effective against multiple-drug-resistant falciparum malaria, but nothing is known about mefloquine absorption when it is given in this formulation. Nine Thai patients, aged 15-51 years with uncomplicated chloroquine-resistant falciparum malaria, took 11.2-16.7 mg of mefloquine base per kilogram bodyweight as MSP tablets. All patients responded to treatment with fever and parasite clearance times of 61 +/- 29 h (mean +/- s....

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Publication status:
Published

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Authors


Karbwang, J More by this author
Looareesuwan, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Wattanagoon, Y More by this author
Molyneux, ME More by this author
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Journal:
British journal of clinical pharmacology
Volume:
23
Issue:
4
Pages:
477-481
Publication date:
1987-04-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:b047ac63-6682-4f08-a948-7e30d8934170
Source identifiers:
5247
Local pid:
pubs:5247

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