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A simple mechanistic model of sprout spacing in tumour-associated angiogenesis.

Abstract:

This paper develops a simple mathematical model of the sitting of capillary sprouts on an existing blood vessel during the initiation of tumour-induced angiogenesis. The model represents an inceptive attempt to address the question of how unchecked sprouting of the parent vessel is avoided at the initiation of angiogenesis, based on the idea that feedback regulation processes play the dominant role. No chemical interaction between the proangiogenic and antiangiogenic factors is assumed. The m...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2007.08.030

Authors


Addison-Smith, B More by this author
McElwain, DL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Journal:
Journal of theoretical biology
Volume:
250
Issue:
1
Pages:
1-15
Publication date:
2008-01-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:b043e7e8-fb0a-465c-b82a-2f49e6541126
Source identifiers:
15561
Local pid:
pubs:15561

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