Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements.

Journal article

Epidemiological studies have shown that higher blood homocysteine levels appear to be associated with higher risks of coronary, cerebral, and peripheral vascular disease and are inversely related to blood levels of folate and of vitamin B12 and vitamin B6. However, observational studies cannot exclude the possibility that elevated homocysteine levels may be associated with some other factor, rather than being causally related to vascular disease. Large-scale clinical trials of sufficient dose...

Expand abstract

Authors: Clarke, R; Armitage, J

• Publication status: Published
• Journal: Seminars in thrombosis and hemostasis
• Volume: 26
• Issue: 3
• Pages: 341-348
• Publication date: 2000-01-01
• DOI: 10.1055/s-2000-8101
• EISSN: 1098-9064
• ISSN: 0094-6176
• Language: English
• Keywords: Treatment Outcome; Female; Humans; Randomized Controlled Trials as Topic; Homocysteine; Prospective Studies; Cardiovascular Diseases; Hyperhomocysteinemia; Forecasting; Multicenter Studies as Topic; Vitamin B 12; Research Design; Folic Acid; Male; Clinical Trials as Topic; Intervention Studies; Aged; Diet; North America; Double-Blind Method; Meta-Analysis as Topic; Europe; Genetic Variation; Risk Factors; Drug Synergism; Middle Aged; Adult