Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy.

Conference item

Genetically determined differences in immune responses to environmental agents may underlie susceptibility to many autoimmune and infectious diseases. Leprosy provides an example of a polarity in the type of immune response made to an infectious agent, and there is evidence that the major histocompatibility complex is genetically linked to leprosy type. It was found that HLA-DR2 is associated with both tuberculoid and lepromatous types of leprosy; however, a variant at position -308 of the pr...

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Authors: Roy, S; McGuire, W; Mascie-Taylor, C; Saha, B; Hazra, S

• Publication status: Published
• Host title: The Journal of infectious diseases
• Volume: 176
• Issue: 2
• Pages: 530-532
• Publication date: 1997-08-01
• Event location: UNITED STATES
• DOI: 10.1086/517282
• EISSN: 1537-6613
• ISSN: 0022-1899
• Keywords: Gene Frequency; Genes, MHC Class II; Polymorphism, Genetic; Female; Leprosy, Lepromatous; Disease Susceptibility; Leprosy, Tuberculoid; Male; Humans; Case-Control Studies; Promoter Regions, Genetic; Adult; HLA-DR2 Antigen; Tumor Necrosis Factor-alpha