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Finding the molecular basis of quantitative traits: successes and pitfalls.

Abstract:

Understanding the molecular basis of quantitative genetic variation is a principal goal for biomedicine. Although the complex genetic architecture of quantitative traits has so far largely frustrated attempts to identify genes in humans by standard linkage methodologies, quantitative trait loci (QTL) have been mapped in plants, insects and rodents. However, identifying the molecular bases of QTL remains a challenge. Here, we discuss why this is and how new experimental strategies and analytic...

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Publication status:
Published

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Publisher copy:
10.1038/35076585

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Nature reviews. Genetics
Volume:
2
Issue:
6
Pages:
437-445
Publication date:
2001-06-05
DOI:
EISSN:
1471-0064
ISSN:
1471-0056
URN:
uuid:b02e7d21-b91a-4d1c-b879-d20cf0ec6093
Source identifiers:
31894
Local pid:
pubs:31894

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