Thrombolytic therapy for acute ischemic stroke with lower than standard dose of intravenous alteplase may improve recovery with reduced risk of intracerebral hemorrhage (ICH).
Using a 2-by-2 quasi-factorial open label design, we randomly assigned 3310 patients eligible for thrombolytic therapy (median age 67 years, 63% Asian) within 4.5 hours of stroke onset, to test for noninferiority of low-dose (0.6mg/kg) compared with standard-dose (0.9mg/kg)...Expand abstract
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