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Low versus standard dose intravenous alteplase in acute ischemic stroke

Abstract:

Background

Thrombolytic therapy for acute ischemic stroke with lower than standard dose of intravenous alteplase may improve recovery with reduced risk of intracerebral hemorrhage (ICH).

Methods

Using a 2-by-2 quasi-factorial open label design, we randomly assigned 3310 patients eligible for thrombolytic therapy (median age 67 years, 63% Asian) within 4.5 hours of stroke onset, to test for noninferiority of low-dose (0.6mg/kg) compared with standard-dose (0.9mg/kg)...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1056/NEJMoa1515510

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
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National Health and Medical Research Council More from this funder
Stroke Association More from this funder
Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Volume:
374
Issue:
24
Pages:
2313-2323
Publication date:
2016-04-05
DOI:
ISSN:
1533-4406
URN:
uuid:b0266b00-cc06-4404-94fb-0d53b86911e8
Source identifiers:
616639
Local pid:
pubs:616639

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