Low versus standard dose intravenous alteplase in acute ischemic stroke
Thrombolytic therapy for acute ischemic stroke with lower than standard dose of intravenous alteplase may improve recovery with reduced risk of intracerebral hemorrhage (ICH).
Using a 2-by-2 quasi-factorial open label design, we randomly assigned 3310 patients eligible for thrombolytic therapy (median age 67 years, 63% Asian) within 4.5 hours of stroke onset, to test for noninferiority of low-dose (0.6mg/kg) compared with standard-dose (0.9mg/kg)...Expand abstract
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- Peer reviewed
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