- Abstract:
-
The ability of oligonucleotides to silence specific genes or inhibit the biological activity of specific proteins has generated great interest in their use as research tools and therapeutic agents. Unfortunately, their biological applications meet the limitation of their poor cellular accessibility. Developing an appropriate delivery system for oligonucleotides is essential to achieve their efficient cellular uptake. In the present work a series of phosphorothioate lipid–oligonucleotide hybri...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1016/j.bmc.2016.10.024
-
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- Grant:
- CTQ2014-52588-R, CTQ2014-61758-EXP and BFU2012-36241
- Publisher:
- Elsevier Publisher's website
- Journal:
- Bioorganic and Medicinal Chemistry Journal website
- Volume:
- 25
- Issue:
- 1
- Pages:
- 175-186
- Publication date:
- 2016-10-20
- Acceptance date:
- 2016-10-19
- DOI:
- EISSN:
-
1464-3391
- ISSN:
-
0968-0896
- Pubs id:
-
pubs:745334
- URN:
-
uri:b0252afe-4ec1-4f6e-a93e-5549b75914be
- UUID:
-
uuid:b0252afe-4ec1-4f6e-a93e-5549b75914be
- Local pid:
- pubs:745334
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Ltd
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Elsevier Ltd.
Journal article
Lipid-modified oligonucleotide conjugates: Insights into gene silencing, interaction with model membranes and cellular uptake mechanisms
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+ Spanish Ministry of Education
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