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Lipid-modified oligonucleotide conjugates: Insights into gene silencing, interaction with model membranes and cellular uptake mechanisms

Abstract:

The ability of oligonucleotides to silence specific genes or inhibit the biological activity of specific proteins has generated great interest in their use as research tools and therapeutic agents. Unfortunately, their biological applications meet the limitation of their poor cellular accessibility. Developing an appropriate delivery system for oligonucleotides is essential to achieve their efficient cellular uptake. In the present work a series of phosphorothioate lipid–oligonucleotide hybri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bmc.2016.10.024

Authors


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Role:
Author
ORCID:
0000-0002-8405-4844
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Grant:
CTQ2014-52588-R, CTQ2014-61758-EXP and BFU2012-36241
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Publisher:
Elsevier Publisher's website
Journal:
Bioorganic and Medicinal Chemistry Journal website
Volume:
25
Issue:
1
Pages:
175-186
Publication date:
2016-10-20
Acceptance date:
2016-10-19
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
Pubs id:
pubs:745334
URN:
uri:b0252afe-4ec1-4f6e-a93e-5549b75914be
UUID:
uuid:b0252afe-4ec1-4f6e-a93e-5549b75914be
Local pid:
pubs:745334

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