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Demonstration of voltage-dependent and TTX-sensitive Na(+)-channels in human melanocytes.

Abstract:

The electrophysiological properties of cultured human melanocytes were investigated using the whole-cell configuration of the patch-clamp technique. Depolarizations to membrane potentials more positive than -30 mV resulted in the rapid development ( < 1 ms to peak) of an inward current. The maximum peak current was observed at +10 mV and reached an average amplitude of about 270 pA. During the depolarizations, the current inactivated with a time constant of about 2 ms. The current was abol...

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Publication status:
Published

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Volume:
7
Issue:
5
Pages:
333-338
Publication date:
1994-10-05
DOI:
EISSN:
1600-0749
ISSN:
0893-5785
URN:
uuid:b01e5fa2-c971-45ca-8cd6-cfbbcc203765
Source identifiers:
15214
Local pid:
pubs:15214

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