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BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents.

Abstract:

A polymorphism of the human Brain Derived Neurotrophic Factor (BDNF) gene that produces a valine-to-methionine substitution at codon 66 (Val66Met) is linked to adult anxiety and mood disorders, possibly through effects on brain circuitry function. Associations between BDNF gene variants and brain activity have not been explored in anxious and depressed adolescents. The current study investigated the association between BDNF genotype and amygdala-hippocampal responses to emotional stimuli in a...

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Publication status:
Published

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Authors


Goldman, D More by this author
Hodgkinson, C More by this author
Leibenluft, E More by this author
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Journal:
NeuroImage
Volume:
53
Issue:
3
Pages:
952-961
Publication date:
2010-11-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:b019a1d3-da7c-4efa-b720-bae57b617cd4
Source identifiers:
83846
Local pid:
pubs:83846

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