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Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"?

Abstract:

Immunological memory is a key characteristic of specific immune responses. Persistence of increased levels of precursor T cells is antigen-independent and is often used as an indicator of T cell memory. This study documents that, depending on the chosen readout, cytotoxic T lymphocyte (CTL) memory against lymphocytic choriomeningitis virus (LCMV) appears long- or short-lived in the absence of persisting antigen. To study T cell memory in the absence of persisting antigen, either short-lived a...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.94.2.640

Authors


Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
94
Issue:
2
Pages:
640-645
Publication date:
1997-01-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:b0197579-d46c-47ae-b92f-5a9137fbf25e
Source identifiers:
469169
Local pid:
pubs:469169

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