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Journal article

Post-imaging fiducial markers aid in the orientation determination of complexes with mixed or unknown symmetry.

Abstract:

During the entry process many icosahedral viruses must adopt a lower-order symmetry or incur a symmetry mismatch to release their genome through a single site. A membrane model system in which poliovirus was bound to receptor-decorated liposomes was used to pioneer techniques that studied the break in the symmetry of the initial attachment complex by cryo-electron microscopy. Novel methods involving a fiducial marker for the membrane contact point were developed to objectively determine the s...

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Publication status:
Published

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Publisher copy:
10.1016/j.jsb.2008.03.006

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Filman, DJ More by this author
Fuller, SD More by this author
Journal:
Journal of structural biology
Volume:
162
Issue:
3
Pages:
480-490
Publication date:
2008-06-05
DOI:
EISSN:
1095-8657
ISSN:
1047-8477
URN:
uuid:b01680f8-21de-460b-9e41-4c92bd297ba4
Source identifiers:
34213
Local pid:
pubs:34213

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