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Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion

Abstract:

Genomic imprinting directs the allele-specific marking and expression of loci according to their parental origin. Differential DNA methylation at imprinted control regions (ICRs) is established in gametes and, although largely preserved through development, can be experimentally reset by fusing somatic cells with embryonic germ cell (EGC) lines. Here, we show that the Ten-Eleven Translocation proteins Tet1 and Tet2 participate in the efficient erasure of imprints in this model system. The fus...

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Authors


Piccolo, FM More by this author
Landeira, D More by this author
Soza-Ried, J More by this author
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Journal:
Molecular Cell
Volume:
49
Issue:
6
Pages:
1023-1033
Publication date:
2013-03-28
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:b006c6d1-5d19-4176-9ffd-0d310f65cd73
Source identifiers:
396096
Local pid:
pubs:396096
Language:
English

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