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Binding site flexibility: molecular simulation of partial and full agonists within a glutamate receptor.

Abstract:

Ionotropic glutamate receptors mediate fast synaptic transmission in the mammalian central nervous system and play an important role in many different functions, including memory and learning. They have also been implicated in a variety of neuropathologies and as such have generated widespread interest in their structure and function. Molecular Dynamics simulations (5 x 20 ns) of the ligand-binding core of the GluR2 glutamate receptor were performed. Through simulations of both wild type and ...

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Publication status:
Published

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Publisher copy:
10.1124/mol.105.016691

Authors


Arinaminpathy, Y More by this author
Sansom, MS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Molecular pharmacology
Volume:
69
Issue:
1
Pages:
11-18
Publication date:
2006-01-05
DOI:
EISSN:
1521-0111
ISSN:
0026-895X
URN:
uuid:affd573d-a73a-4e15-99b6-8cc3e537c443
Source identifiers:
100293
Local pid:
pubs:100293

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