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Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone.

Abstract:

Central orexin/hypocretin neurones are critical for sustaining consciousness: their firing stimulates wakefulness and their destruction causes narcolepsy. We explored whether the activity of orexin cells is modulated by thyrotropin-releasing hormone (TRH), an endogenous stimulant of wakefulness and locomotor activity whose mechanism of action is not fully understood. Living orexin neurones were identified by targeted expression of green fluorescent protein (GFP) in acute brain slices of trans...

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Publication status:
Published

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Authors


González, JA More by this author
Horjales-Araujo, E More by this author
Broberger, C More by this author
Burdakov, D More by this author
Journal:
The Journal of physiology
Volume:
587
Issue:
Pt 6
Pages:
1179-1186
Publication date:
2009-03-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:aff4806a-389f-489a-897a-aee0de73dfe3
Source identifiers:
314773
Local pid:
pubs:314773

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