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Divergent effects of hypoxia on dendritic cell functions.

Abstract:

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that patrol tissues to sense danger signals and activate specific immune responses. In addition, they also play a role in inflammation and tissue repair. Here, we show that oxygen availability is necessary to promote full monocyte-derived DC differentiation and maturation. Low oxygen tension (hypoxia) inhibits expression of several differentiation and maturation markers (CD1a, CD40, CD80, CD83, CD86, and MHC class II molec...

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Publication status:
Published

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Authors


Mancino, A More by this author
Schioppa, T More by this author
Pasqualini, F More by this author
Nebuloni, M More by this author
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Journal:
Blood
Volume:
112
Issue:
9
Pages:
3723-3734
Publication date:
2008-11-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:aff40df6-3750-4f8c-b9ed-f45bfd963fb6
Source identifiers:
140889
Local pid:
pubs:140889

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