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Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports

Abstract:

Introduction: Patient adherence to therapy in clinical practice is often low, and the difference between efficacy measured in clinical trials and effectiveness in clinical practice is probably a function of discontinuation of therapy because lack of efficacy or because of unmanageable or intolerable adverse events. Discontinuation is frequently measured in clinical trials but is not usually described in detail in published reports, often because of limitations in the size of publications. By ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/ar2422

Authors


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Institution:
University of Oxford
Research group:
Pain Research
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Anaesthetics
More by this author
Institution:
University of Oxford
Research group:
Pain Research
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Anaesthetics
More by this author
Institution:
University of Oxford
Research group:
Pain Research
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Anaesthetics
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Arthritis Research & Therapy Journal website
Volume:
10
Issue:
3
Pages:
Article: R53
Publication date:
2008-05-05
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:afeaabad-90bb-4a68-9477-0a9db4cfed52
Local pid:
ora:2394

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