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Journal article

Vaccine-induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies.

Abstract:

Secretory IgA (SIgA) is widely held to be responsible for the defense of the mucosae against pathogenics and other potentially harmful agents. In this study, polymeric Ig receptor (pIgR) knockout mice, which lack secretory antibodies (SAb), were used to investigate the role of vaccine-elicited SAb in protection against gastrointestinal bacterial infections. An essential role for specific SAb in protection against Vibrio cholerae was evident from experiments showing that vaccinated pIgR(-/-) m...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200425492

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Journal:
European journal of immunology
Volume:
35
Issue:
1
Pages:
180-188
Publication date:
2005-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:afe660c2-ed85-4c90-97dd-06f09314b1d9
Source identifiers:
98264
Local pid:
pubs:98264

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