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Mass measurements of increased accuracy resolve heterogeneous populations of intact ribosomes.

Abstract:

It is established that noncovalent complexes can be maintained both during and after electrospray and that assemblies of increasing size and complexity often lead to broadened peaks in mass spectra. This broadening arises from the tendency of large protein assemblies to form adducts with salts and is compounded when complexes are isolated directly from cells, without the full protein complement. To investigate the origins of this broadening in mass spectral peaks and to develop the optimal me...

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Publication status:
Published

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Publisher copy:
10.1021/ja061468q

Authors


Ruotolo, BT More by this author
Robinson, CV More by this author
Journal:
Journal of the American Chemical Society
Volume:
128
Issue:
35
Pages:
11433-11442
Publication date:
2006-09-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:afdb68a3-aadd-4ed7-b722-d18337d2200d
Source identifiers:
59295
Local pid:
pubs:59295

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