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Journal article

Algebra, geometry and topology of ERK kinetics

Abstract:

The MEK/ERK signalling pathway is involved in cell division, cell specialisation, survival and cell death (Shaul and Seger in Biochim Biophys Acta (BBA)-Mol Cell Res 1773(8):1213–1226, 2007). Here we study a polynomial dynamical system describing the dynamics of MEK/ERK proposed by Yeung et al. (Curr Biol 2019, https://doi.org/10.1016/j.cub.2019.12.052) with their experimental setup, data and known biological information. The experimental dataset is a time-course of ERK measurements in dif...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s11538-022-01088-2

Authors


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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-6740-8436
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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0003-1771-5910
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Institution:
University of Oxford
Role:
Author
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Name:
Engineering & Physical Sciences Research Council
Grant:
EP/R005125/1
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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/R018472/1
EP/T001968/1
Publisher:
Springer
Journal:
Bulletin of Mathematical Biology More from this journal
Volume:
84
Issue:
12
Article number:
137
Publication date:
2022-10-23
Acceptance date:
2022-09-16
DOI:
EISSN:
1522-9602
ISSN:
0092-8240
Pmid:
36273372
Language:
English
Keywords:
Pubs id:
1287516
Local pid:
pubs:1287516
Deposit date:
2022-12-12

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